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Furthermore, through the use of in vivo reporter systems, rapamycin treatment has been shown to induce autophagy in both the nervous system and pancreatic cells of mice (98, 99)

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Pastoris et al

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T-ALL PDXs were treated with vehicle, ATO (2.5 mg/kg), MTX (5 mg/kg for BCP-ALL

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When catalyzed by GST, the prodrug releases cytotoxic compounds

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