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Heme oxygenase-1 (HO-1) HO-1 is a crucial enzyme involved in the catabolism of heme, which has garnered significant attention in recent years due to its role in the regulation of ferroptosis

We intracranially implanted GSCs into BALB/c nude mice to established orthotopic GB xenografts for twenty days, and treated them with ionizing radiation (IR) (3 Gy) to simulate radiotherapy