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In several reported pediatric cases, ingestion of large amounts of alpha-lipoic acid (for example, 2400 mg in a toddler) led to serious reactions such as seizures, loss of consciousness, or metabolic acidosis

Graphical Abstract Similar content being viewed by others Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by social communication impairments and repetitive behaviors, with an estimated global prevalence of 0.72% [1]

Such fragmentation impairs substrate and protein exchange across the mitochondrial network, compromises m and reduces coupling efficiency between electron transport and ATP synthesis