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It contains methylphenidate, a central nervous system stimulant, and is formulated as a long-acting tablet designed to provide symptom control throughout the day

In AD research, Wistar rats have been instrumental in understanding critical aspects of neuroinflammation, tau hyperphosphorylation, amyloid-beta (A) aggregation, oxidative stress, and cholinergic dysfunction

Confirmed cases require genetic or biopsy evidence, clinical-imaging features, and a first-degree relative

Note that due to the relative small size of the rats, rat fistulas regularly appeared as large and complex, and thereby, in this respect, corresponded to the worst presentation in the patients (Klicek et al., 2008