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The increase of DA promotes the dopaminergic transmission by regulating (inhibiting) other proteins: VMAT2, whose inhibition induces the DA liberation from vesicular storage and the concomitant release of cytosolic DA via DAT reverse transport [33, 187], SERT (with weaker affinity), and MAOA and MAOB [153]

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This limitation reflects a broader gap in the field: most randomized controlled trials and systematic reviews focus on major depressive disorder or depressive symptoms in heterogeneous populations, without separate analyses for distinct presentations like vascular depression, treatment-associated depressive states, or mood disturbances in the context of specific medical conditions

D., Vassi, E., Alvanou, M., Angelakis, C., Skaperda, Z., Tekos, F., Garikipati, V