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Older adults and people with more serious, chronic challenges are less fortunate, and some people have adverse effects with high levels of NAC use

These compounds, in the course of their auto-oxidation, produce free radicals, which in turn oxidize GSH and thereby activate the chain reaction of events previously outlined

In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

To evaluate the impact of ChP BMAL1 downregulation on astrocytic responses to amyloid plaques and on aquaporin 4 (AQP4) polarization, we performed GFAP staining to examine changes in astrocytes surrounding plaques (Fig