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Description

Hamdan, S.M

Jiang et al engineered a hybrid system (TSEL) by integrating MSC exosomes with liposomes to co-deliver two gene therapeutics: -site amyloid precursor protein cleaving enzyme 1 (BACE1) siRNA (siBACE1) and triggering receptor expressed on myeloid cells 2 (TREM2) plasmid (pTREM2)

For that, the -glutamate-cysteine ligase (GshA) condenses the carboxyl group at the -position of glutamate with the amino group of cysteine, creating the dipeptide -glutamyl-cysteine