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HAX-1 has been recently identified as a binding partner for canalicular Bsep, Mdr1, and Mdr2.104 There is evidence that HAX-1 and cortactin participate in clathrin-mediated Bsep endocytosis from the canalicular plasma membrane,126 and that cortactin location in the cell cortex depends on an intact actin cytoskeleton.104 Again, further elucidation of the process regulating the interplay between canalicular transporters and actin-associated proteins should be directed to understand the mechanisms underlying the canalicular-transporter internalization under redox-imbalance conditions

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Battaglia, Overcoming the Blood-Brain Barrier: Successes and Challenges In developing Nanoparticle-Mediated Drug Delivery Systems for the Treatment of Brain Tumours, Int J Nanomedicine, 15 (2020) 29993022, W