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marinum and Cortes et al

The Watanabe 2012 trial demonstrated statistically significant melanin reduction using topical 2% glutathione formulations

Power analysis and advanced statistics can potentially help to reduce the number of replicates ( While pseudo-replication due to the re-use of animals can be compensated for using Bayesian statistics ( Pagurus bernhardus ( The number of replicates should then be carefully decided based on such previous experiments with the chosen model organisms