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It retains highly conserved sequences, shares similar domain structures with HIF-1, and binds to the same HRE sequence, 5-(A/G)CGTG-3, in the promoters of specific target genes

Medical procedures Collagen is widely used in dermatology for sutures and to promote wound healing and skin growth

In mammalian nervous systems, many different types of chemical substances, including amino acids (e.g., glutamate), monoamines (e.g., dopamine, norepinephrine), acetylcholine, peptides (e.g., substance P), serve as neurotransmitters to bind their corresponding receptors, then activate ion channels, and consequently produce ion flux 1 , thereby inducing membrane potential changes that lead to signal propagation for neurotransmission 1,2,3,4