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Decreased activity of GPX4 prevents the metabolism of lipid peroxides via GPX4-catalyzed glutathione (GSH) reduction reactions, resulting in the oxidation of divalent iron ions and the generation of reactive oxygen species (ROS) in lipids (19)

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BMJ (Clinical research ed.), 330 (7482), 8587

Acute lethal arsenite poisoning in mice: effect of treatment with n-acetylcysteine, d-penicillamine and dimercaprol on survival time