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In animal studies, AOD-9604 reduced body weight gain by over 50% in obese mice during a 19-day treatment period, and significantly increased fat oxidation all without affecting insulin sensitivity or glucose regulation.[1,3] A randomized controlled trial in humans found that participants taking 1 mg of AOD-9604 daily lost an average of 2.8 kg (~6 lbs) over 23 weeks, compared to 0.8 kg (~1.7 lbs) in the placebo group

Manufacturers are also subject to inspection, and the FDA monitors safety concerns once products are on the market

Oxidative stress was quantified through ROS, nitrites, TBARS, total thiols, and the activities of SOD, CAT GPx, GST, and ALA-D, using spectrophotometric assays and fluorescence-based detection

Urol Oncol 2019;37:63746