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The aim of this study was to prove our hypothesis that A-GSH functionalization increases brain endothelial internalization and BBB permeability of polymeric nanoparticles coupled with active agents, namely dopamine and ibuprofen, which have low brain penetration

In the future, conducting more metabolism-related polarization studies on microglia to delineate their roles and mechanisms may be a crucial research direction

Vitamin C is a cofactor for a family of metalloenzymes with pleotropic biosynthetic and gene regulatory roles ( Gulo knockout mice with melanoma and breast tumors following supplementation with low dose oral vitamin C (0.15 g/L, Figure 1 ) (Polireddy et al., 2017)

In contrast to monothiols, addition of the dithiol DTT to WT completely inhibited roGFP2 re-oxidation