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In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)

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Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration

Moreover, TEM revealed alternations in cell morphology, including shrunken mitochondria with increased bilayer density 43 in TB m A-Glu + light-treated cells, which were the symbols of ferroptosis (Fig