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The integrin 1/5/JNK/c-JUN signaling pathway in cancer cells is able to upregulate the higher matrix stiffness-induced lysyl oxidase like (LOXL)-2, then subsequently promote production of fibronectin, expression of MMP-9 and C-X-C motif chemokine ligand (CXCL)-12 and recruitment of BMDCs to encourage pre-metastatic niche establishment (95)

doi: 10.1016/j.msard.2023.105364 69 GiovannoniG.PopescuV.WuerfelJ.HellwigK.IacobaeusE.JensenM

Cartilage metabolism: IGF-1 stimulates chondrocyte proteoglycan and collagen synthesis

Skin irritation can create post-inflammatory hyperpigmentation Deep peels, laser treatments, plasma pens, harsh skincare, and allergic reactions that happen to the skin can cause post-inflammatory hyperpigmentation