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Spicer J, Shewale J, Antonoff M, Correa A, Hofstetter W, Rice D, Vaporciyan A, Mehran R, Walsh G, Roth J, Swisher S , Sepesi B

argue against framing ADHD as a disorder because it exists on a spectrum without a clear cutoff, its manifestation is context-dependent, and its definition evolves

doi: 10.1093/plphys/kiac095 132 ZhaoM.YangS.LiuX.WuK

Abbreviations Akt Protein kinase B CDKs Cyclin-dependent kinases ERK Extracellular-signal-regulated kinases IB Inhibitor of NF-B IKK IB kinase IGF Insulin-like growth factor IL-1 Interleukin-1 IL-2 Interleukin-2 IL-6 Interleukin-6 JNK C-Jun N-terminal kinases LPS Lipopolysaccharides MAPK Mitogen-activated protein kinase MREs Metal-response elements MT Metallothionein MTF-1 Metal-regulatory transcription factor 1 NF-B Nuclear factor kappa B NK cells Natural killer cells PI3K Phosphatidylinositol 3-Kinase ROS Reactive oxygen species SOD Superoxide dismutase Sp1 Specificity protein 1 TNF- Tumor necrosis factor-alpha TRAF2 TNF receptor-associated factor 2 ZnT1 Zinc transporter 1 ZnT2 Zinc transporter 2 ZnT3 Zinc transporter 3 ZnT4 Zinc transporter 4 Authors contributions ZLC: Conceptualization, Visualization and Writing original draft