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8 Conclusion The ctDCS has emerged as a promising non-invasive technique for modulating nociceptive processing and may provide therapeutic benefits for individuals with chronic paineven after a single session

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Hyperalgesia and Allodynia: Cases of hyperalgesia and allodynia have been reported with opioid therapy of any duration (see WARNINGS)

However, once its ability to interact with high affinity with E2 was determined, GPR30 was renamed GPER-1 (G protein-coupled estrogen receptor 1) (Revankar et al., 2005)