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283,320,321 Moreover, combination therapy is more effective than SC transplantation alone, which may be a future direction

Overdose reactive intermediates/reactive metabolites are also liable to covalently bind to cellular proteins or DNA (Yan et al., 2008), and eventually initiate and trigger a series of toxic effects, including protein abnormal modification, enzyme inactivation, DNA crosslink, formation of immunogenic species, cell death, or oncogene activation, organ injury ( The present review focuses on the toxicity of natural products, analyzing the key role of metabolic activation in their toxicities

Once regarded as inert storage depots, LDs are now recognized as active immunometabolic hubs that sequester toxic lipids and release pro-inflammatory mediators, including prostaglandin E2 (PGE2) [117, 118]

Commercial CGMs, such as the Dexcom G7 and Freestyle Libre 3, position the WE within the deep dermal compartment, approximately 5 mm below the skin surface