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Epub 2018 Aug 15

Figure 3: Kaplan-Meier Curves for Overall Survival in Non-squamous NSCLC in Study JMDB Maintenance Treatment Following First-line Non-Pemetrexed Containing Platinum-Based Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was evaluated in Study JMEN (NCT00102804), a multicenter, randomized (2:1), double-blind, placebo-controlled study conducted in 663 patients with Stage IIIb/IV NSCLC who did not progress after four cycles of platinum-based chemotherapy

General observations: High doses may cause mild digestive upset in some people Sensitive individuals occasionally report headaches or restlessness People with kidney conditions or rare genetic disorders should be cautious If youre pregnant, elderly, managing chronic illness, or already taking medications, its usually sensible to discuss supplementation with a qualified professional

Diarrhea or constipation : Gastrointestinal effects are central to GLP-1 mechanisms