glutathione polysulfide Acid-catalyzed esterification and biotin/fluorescent labeling of polysulfides based on stability under heating and pH change certified reference material Untargeted polysulfide omics analysis of

Conclusion An essential antioxidant, glutathione is involved in inflammation, immunity, and detoxification

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AIF: apoptosis-inducing factor AKR: aldo-keto reductase ALDH: aldehyde dehydrogenase ALE: advanced lipid peroxidation end product AP-1: activator protein 1 ASK1: apoptosis signal-regulating kinase 1 Bcl2: B-cell lymphoma 2 Cdc: cell division cycle homolog CDK: cyclin-dependent kinase cyt.c: cytochrome c Daxx: death domain-associated protein DHN: 1,4-dihydroxy-2-nonene DISC: death-inducing signaling complex ER: endoplasmic reticulum FADD: Fas-associated protein with death domain FasL: Fas ligand GSH: glutathione GST: gluthatione S-transferase HNA: 4-hydroxynonenoc acid HNE: 4-hydroxy-2-nonenal HO-1: heme oxygenase 1 HSF: heat shock factor Hsp: heat shock protein hTERT: human telomerase reverse transcriptase I B: inhibitor of kappa B IKK: I B kinase JNK: c-Jun N-terminal kinase Keap-1: Kelch-like ECH-associated protein 1 LDL: low-density lipoprotein LMP: lysosomal membrane permeabilization LPO: lipoperoxidation MCP-1: monocyte chemotactic protein 1 MOMP: mitochondrial outer membrane permeabilization MRP: multidrug-resistant protein NAFLD: non-alcoholic fatty liver disease NDD: neurodegenerative diseases NF B: nuclear factor-kappa B NQO1: NAD(P)H dehydrogenase (quinone) 1 Nrf2: Nuclear factor (erythroid-derived 2)-like 2 p53: tumor protein 53 PDGFR: platelet-derived growth factor receptor PUFA: polyunsaturated fatty acid Rb: retinoblastoma protein RLIP76: RalA-binding protein 16 encoded 76-kDa splice variant ROS: reactive oxygen species TGF : transforming growth factor Trx1: thioredoxin reductase 1 TNF: tumor necrosis factor TRAIL: TNF-related apoptosis-inducing ligand UPR: unfolded protein response VSMC: vascular smooth muscle cells XIAP: X-linked inhibitor of apoptosis protein References Schaur RJ

Specificity was 0.93 for APRI, 0.71 for FIB-4, 0.57 for NFS, 0.43 for BARD and 0.79 for BMI50+

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