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However, due to the replication and liberation of SARS-CoV-2, regulated necrosis releases a large number of pathogen-associated molecular patterns (PAMP) and damage-associated molecular patterns (DAMP), including inflammatory cytokines and cell contents such as SARS-CoV-2 particles, chemokines, lactate dehydrogenase, adenosine triphosphate (ATP), and reactive oxygen species (ROS)