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The absence of both 5' caps and 3' polyadenylated tails renders circRNAs resistant to exonuclease-mediated degradation, thus ensuring their stability and longevity in cellular processes (158)

BI 425809 has been investigated in a phase II trial involving patients with Alzheimers disease, where the compound was administered at doses of 225 mg over 12 weeks, failing to demonstrate significant cognitive improvements (Wunderlich et al

Macoskos group on the single cell portal 14 to extract seven cell types: dopaminergic neurons, non-dopaminergic neurons, astrocytes, oligodendrocytes, oligodendrocyte progenitor cells (OPCs), endothelial cells/pericytes and microglia/macrophages

Anecdotally reported side effects include nausea, headache, dizziness, and injection-site reactions for BPC-157, and mild fatigue for TB-500