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A 2026 biopharmaceutical review in a journal I do not trust said there is no identified high-affinity receptor, no validated molecular target, and a wide disconnect between the tidy preclinical effects and any coherent pharmacology

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For example, many lipolytic proteins such as PLIN1 (13, 130), PNPLA2 (131, 132) and G0S2 (133) are stabilized by condition that promote LD biogenesis, such as oleic acid supplementation, where association with the phospholipid monolayer is thought to mask motifs that signal degradation