Though unlikely with typical product concentrations that fall within safe parameters, awareness of this risk remains important
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Regarding the vectors of green tea supplements used in the intervention, 12 studies used green tea extract, (Reference Rondanelli, Gasparri and Perna32,Reference Kondori, Ghaleh and Hosseini35,Reference Shin, Lee and Seo42,Reference Hussain, Habib Ur and Akhtar48,Reference Hadi, Pourmasoumi, Kafeshani, Karimian, Maracy and Entezari49,Reference Kuo, Lin, Bernard and Liao52,Reference Spadiene, Savickiene and Ivanauskas53,Reference Liu, Huang, Huang, Chen, Chiu and Hsu55,Reference Lasaite, Spadiene, Savickiene, Skesters and Silova56,Reference Bogdanski, Suliburska, Szulinska, Stepien, Pupek-Musialik and Jablecka60,Reference Mohammadi, Hosseinzadeh Attar and Karimi63,Reference Li, Chen and Aldini64) 9 studies used epigallocatechin-3-gallate (EGCG), (Reference Bazyar, Hosseini and Saradar36Reference Benlloch, Cuerda Ballester and Drehmer38,Reference Maeda-Yamamoto, Nishimura and Kitaichi43,Reference Borges, Papadimitriou, Duarte, Lopes de Faria and Lopes de Faria51,Reference Mielgo-Ayuso, Barrenechea, Alcorta, Larrarte, Margareto and Labayen54,Reference Basu, Betts, Mulugeta, Tong, Newman and Lyons58,Reference Suliburska, Bogdanski, Szulinska, Stepien, Pupek-Musialik and Jablecka59,Reference Basu, Du and Sanchez62) 5 studies used green tea catechins, (Reference Ahmad Merza Mohammad31,Reference Venkatakrishnan, Chiu and Cheng41,Reference Sone, Kuriyama and Nakaya61,Reference Fukino, Ikeda, Maruyama, Aoki, Okubo and Iso65,Reference Erba, Riso, Bordoni, Foti, Biagi and Testolin66) and other studies used green tea leaves
Quantification of the fluorescence emission by area Perimeters were drawn around the nuclei following the area marked with Hoechst, and the mean of nuclear CMFDA fluorescence was obtained (100 cells per condition in 3 separate experiments)
