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Transcriptomic and Metabolomic Changes Reveal the Immunomodulatory Function of Casein Phosphopeptide-Selenium Chelate in Beagle Dogs

Accumulated AGEs bind to membrane receptors on endothelial cells and promote the onset of tissue damage and the activation of the proinflammatory pathway that involves the NFB transcription factor responsible for regulating the expression of other inflammatory cytokines (Figure 4) [37]