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We then identified redox-modifying drugs that can potentiate artemisinin activity both in vitro and in vivo , and showed that sulforaphane (SFN), a common nutraceutical derived from broccoli sprout, can potentiate artemisinin activity against artemisinin resistant parasites both in vitro and in vivo

Moreover, the synergistic effect of AMPK and SIRT1 significantly enhances fatty acid oxidative metabolism, increasing cellular energy utilization efficiency (23, 53)

Materials and Methods Ethical Consideration The Ethical Committees guidelines approved the experiments for handling and using laboratory animals

Moreover, early studies on HIV-1-infected subjects associated GSH deficiency with a poor lymphocytic response and impaired survival following HIV-1 infections 28,29,30 , implying a role for GSH in disease