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Dawson, S

doi: 10.1158/0008-5472.CAN-10-2668 108 La MonicaSMinariRCretellaDFlamminiLFumarolaCBonelliMet al

Regarding DM-associated gastrointestinal pathophysiology, studies demonstrate hyperglycemia-driven systemic inflammation through three key mechanisms: (1) Downregulation of intestinal tight junction proteins (e.g., ZO-1) enhances gut permeability, enabling systemic translocation of pathogen-associated molecular patterns (PAMPs, e.g., LPS)