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Firstly, focusing on antioxidant and metabolic regulatory mechanisms, silybin can activate the Nrf2 signaling pathway, enhancing the expression of intracellular antioxidant enzymes (such as superoxide dismutase and glutathione), effectively clearing reactive oxygen species (ROS) and alleviating oxidative stress damage ( In terms of modulating inflammation signaling within the liver, conditioned medium from Kupffer cells treated with a high-fat diet or palmitic acid promotes liver inflammation

These peptides (Supplementary Table 1) still required DMSO for solubilization

10.1080/15476278.2016.1194148 Organogenesis 274 ZhangQ.RiddleR

The combination creates a broader regenerative environment, and the two compounds do not compete for the same receptors