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Both T-bet + B cells and activated naive B cells in lupus patients demonstrate downregulation of the gene TNF receptor-associated factor 5, a mediator of T: B interactions that regulates CD40 signaling and negatively modulates TLR signaling

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Taking advantage of the Se-Hg interaction in biological systems, experimental studies have been directed at the potential protective effects of organic selenocompounds against MeHginduced toxicity (Farina et al., 2003a, Farina et al., 2003b

Senolytics: targeting senescent cells for age-associated diseases