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The recommendations for switching treatments are shown in Table 9.54,55 Second-line treatments Lamotrigine and baclofen are second-line treatments for TN (class II, grade of recommendation B)

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What the Clinical Evidence Shows What the Clinical Evidence Shows B12 deficiency and metabolic phenotype A 2023 study of children, adolescents, and young adults found low serum B12 was associated with worse metabolic phenotype across the weight spectrum