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doi: 10.2527/jas.2011-4358 34 MavalliMDDiGirolamoDJFanYRiddleRCCampbellKSvan GroenTet al

5-Amino-1MQs potential lies in breaking this cycle essentially keeping more NAD+ in circulation so cells can function optimally

A recurring theme across these studies is that mitochondrial dysfunction parallels NAD + metabolism alterations, contributing to the detrimental phenotypes in different tissues or at the organism level