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Moreover, isoflavones such as daidzein, genistein, and glycitein have been investigated for their potential interactions with thyroid hormone transporter proteins, including MCT8, which confer importance in disorders such as Allan-Herndon-Dudley syndrome (AHDS) (Shaji, 2018)

However, there does appear to be a genetic component as approximately 40 to 50 percent of patients with primary RLS have a family history of the disorder and certain genetic variations are associated with the condition (Ferri 2012