glutathione mutations in sclc patients Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs therapy Oncology Reports

discussion 10-2

These ligands activate AHR signaling in intestinal epithelial cells and type 3 innate lymphoid cells (ILC3s), helping to maintain a dynamic intestinal barrier defense (Hou et al., 2021

15 It is particularly interesting that these examples of tumour-associated auxotrophy are centred around two reactions that utilise aspartate to synthesise other amino acids, both directly (ASNS and ASS1) and indirectly (GS, through regeneration of glutamine required for ASNS activity)

If deproteinization of plasma prior to storage is necessary for prevention of spontaneous oxidation, then there would have been no difference in levels of GSH between Preparation Condition 1 and Preparation Condition 2, and we would have found no difference in level of total GSH and differences in levels of free GSH, GSSG, and their relative ratio between Preparation Condition 3 and Preparation Condition 4