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10.1111/bcp.12240 36 SidotiA.D'AngeloR.CastagnettiA.VicianiE.ScimoneC.AlibrandiS.et al (2024)

J., Ye, L., Wang, Y

Liver and nervous system The liver plays a role in controlling energy supply during fasting and, when fat metabolism does not function normally, general symptoms may arise

These additional excretion pathways collectively contribute to maintain TMAO balance in the body ( In summary, TMAO metabolism involves converting dietary choline to TMA by gut microbes, oxidizing TMA to TMAO in the liver, and primarily excreting TMAO via the kidney, with minor elimination through sweat, feces, and breath