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( Bmal1 (one of the essential clock genes that participate in the maintenance of the circadian periodicity at the cellular level) in mice suprachiasmatic nucleus (SCN) led to increased escape latencies and number of escape failures in the learned helplessness paradigm, induced higher immobility time in the tail suspension test, and decreased the time spent in the light compartment of the light/dark test

This determines the strongly pro-inflammatory characteristics of this RCD with poorly controlled inflammatory response [128]