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Several studies have confirmed that alterations of the epithelial-mesenchymal-ECM interplay underpin the increase in intestinal permeability, with a significant association with imbalanced ECM proteolytic activity [83]

For instance, relaxin and oxytocin are short peptide hormones that impact uterine tone and cervical remodeling, whereas other experimental peptides seek to reprogram immune cells to prevent miscarriage

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