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Description

Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

Future Directions Screening for New Drugs : Automated techniques can help find better glutaminase inhibitors

By integrating insights from neural development and classical neurodegeneration, this work will inspire future translational research into bilirubin-based therapeutic strategies to prevent or modify the progression of PD