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The difference between the two is that cyanocobalamin is a synthetic form of Vitamin B12 found only in supplements (pills), while methylcobalamin is a naturally occurring form that you can get through either food sources or injections

Abstract Background Pernicious anemia, an autoimmune disease, presents with gradual, nonspecific symptoms, often leading to delayed diagnosis owing to its overlap with other conditions and variability in laboratory findings, such as neurological symptoms without anemia or macrocytosis

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15 A 2023 study found that patients with cognitive impairment who received active B12 (methylcobalamin + adenosylcobalamin) showed significant improvement in cognitive assessment scores after six months compared to controls