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Auguet M, Viossat I, Marin JG, Chabrier PE

Collectively, these data identify TFG as a critical factor upstream of ESCRT-I and thus as having a role early in the ESCRT assembly cascade that enables lysosomal membrane repair

ROS-induced damage to important biomolecules is widely recognized as a significant mechanism contributing to the development of various chronic diseases (Valko et al., 2005[430])