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When evaluating the quality of the 18 articles 2 , 6 , 11 - 26 selected through the Jadad Scale, their scores ranged between 2 and 5, with a median score of 5 (Table 1)

The transcription factor NF-B is an important regulator of immune and inflammatory responses, and NF-B p65-mediated increased trans-activation plays a key role in the pathogenesis of chronic inflammatory diseases (210)

The treatment usually takes 24 weeks depending on the response

Most often, achiral precursors like 3-dehydrocarnitine, crotonobetaine, butyrobetaine or racemic mixtures like D, L-carnitine, D, L-acyl carnitine, and D, L-carnitinamide are biotransformed to produce L-carnitine, which has the highest yield