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Thus, the ATP depletion and mitochondrial ROS burst observed upon SLC25A39 knockdown are expected to blunt PI3K/AKT signaling and subsequently inhibit mTORC1, driving the observed cell death

R747W is a mutant phenotype with loss-of-function of the gene encoding iPLA2, which reduces the hydrolytic activity of 15-HpETE-PE, and increases the content of 15-HpETE-PE in cells, and increases the sensitivity to ferroptosis compared with the wild type

SKT, RS and JK provided technical suggestions and reviewed the manuscript

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