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Method of literature search A systematic search strategy and meta-analysis guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA]) were used to write this review

Lambs need B12 for growth and thermogenesis (heat production)

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Further investigation of mitochondrial 1-C metabolism focusing on the NADPH-producing methylene tetrahydrofolate dehydrogenase 2 (MTHFD2), has led to the discovery of MTHFD2-dependent steroidogenesis in rSCC-61 cells, a pathway previously thought to be present only in tumors of classical steroidogenic tissues (e.g., ovaries, testes)