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As these post-administration concentration profiles of meldonium suggested an incorporation of the substance into the cellular fraction of blood, DPS and spots consisting of washed erythrocytes were additionally analyzed

A recent study showed that long-term erythromycin treatment could modulate lung and intestinal flora and correct metabolite disturbances in mice and patients with COPD, reduce the abundance of pathogenic bacteria, and increase the number of symbiotic bacteria (118)

This review also summarizes and highlights current limitations in targeting the Th17/Treg balance for AR treatment and suggests future research directions, aiming to provide new insights and strategies for clinical management (Fig

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