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This overview was concluded by suggesting that also in Kay's experiments the RBC-specific NAb may have bound to band 3/band 3 aggregates, but ended up in a 62 kDa fragment because of proteolysis (Lutz, 1981)

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Immune cells produce excessive ROS and lead to an oxidative stress microenvironment while killing pathogenic bacteria

Thus, the increased expression and phosphorylation of H2AX /H2ax in Wobbler mice observed in this study indicates a response to existing oxidative stress to trigger a mechanism that, as a consequence, should counteract the loss of function of motor neurons