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Mitochondria as systemic supplements of the cardio-cerebral axis As the central organelles of energy metabolism, mitochondria play a key role as systemic regulatory factors in the highly metabolically active functional axis comprising the heart and brain

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Furthermore, KEGG pathway analysis indicated that the DEGs were significantly enriched in pathways related to protein processing in the endoplasmic reticulum (ER), metabolism, estrogen signaling pathways, Wnt signaling, and MAPK signaling pathways (Fig