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[DOI] [PMC free article] [PubMed] [Google Scholar] 63

observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )

Another aspect of the invention pertains to small molecule quinoline derived cations of Formula IA, wherein: R 5 is H or NH 2 , R 6 is H or F R 7 is H or NH 2 , R 8 is H or methyl