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Kavain, dihydrokavain, and yangonin were also found to inhibit human 1 glycine receptor activity in a concentration-dependent manner in HEK293 cells [87] while the binding of kavalactones and strychnine on the receptor was mutually exclusive [87]

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Lipid rafts facilitate this process by pooling activated receptors and protecting the signaling complex from non-active enzymes, such as membrane phosphatases, that might otherwise disrupt the signaling cascade