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Reversible, plastic resistance in prostate, breast, colon, pancreatic, and non-small cell lung cancer cell line models has been shown to be a consequence of nutrient deprivation which introduces ROS and low cell proliferation, priming cells to adapt to anti-tumor agents such as the mitochondrial ETC Complex I inhibitor metformin (Marini et al., 2016

Mechanistically, the beneficial effect of anthocyanins on cardiovascular health include working as an antiplatelet agent in atherosclerosis and other CVD prevention, inducing nitric oxide formation in vessel thereby enhancing vasorelaxation, protecting cardiac cells from oxidative-stress-induced apoptosis, and increasing HDL cholesterol as well (Gaiz et al., 2018

20,21 Human immunodeficiency virus protease inhibitors (ritonavir, nelfinavir, indinavir) are also recognized CYP3A4 inhibitors