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In 2020, it was estimated that around 523 million people worldwide suffer from some form of CVDs and these have caused approximately 19 million deaths ( Metals impact on humans and their quantification Heavy metals are inorganic elements with a density greater than 5 g/cm 3 ( Metals that act as cofactors for proteins and enzyme systems involved in DNA synthesis, cell differentiation, proliferation, and respiration are called essential

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Typical weight gains did not result in significantly different release profiles of GLP-1 agonists but a weight gain of 46% calculated on the empty capsule which relates to 32.2 mg coating weight gain per size 1 capsule resulted in a dissolution lag time of at least 40 minutes at pH 6

Hence, efficacy and safety were our foremost evaluative factors