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Results: Hydrodynamic tail vein injection of SB AKT/YAP1 resulted in robust tumorigenesis in all fibrotic Mdr2 -/- mice with high CCA burden relative to healthy mice

The currently registered 254 studies (www.clinicaltrials.gov, accessed October 3rd, 2022, under the search term vitamin C) will show if a vitamin C administration really has beneficial treatment effects in critically ill patients

While its traditional use and numerous clinical studies indicate relative safety at typical therapeutic doses [228], emerging data call for a more nuanced evaluation of potential risks

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